Familial amyloidotic polyneuropathy in Crete, Greece

Abstract

Results The mean age of disease onset was 30 years (range: 27 to 43). All patients presented with paresthesias, temperature loss and progressive weakness at the lower extremities, urinary difficulties, diarrhea, postural dizziness and weight loss. The upper extremities were involved later during the disease progression. Neurological examination revealed loss of pain and temperature sensation in a glove and stocking distribution and distal weakness. All but two exhibited orthostatic hypotension. Four patients presented with carpal tunnel syndrome. Although cardiac arrhythmia was a common symptom to most patients, heart failure developed in 3 patients during the late phase of the disease. One patient presented with chronic kidney disease for which she was treated with hemodialysis. Electromyographic examination revealed evidence of denervation in the muscles of the lower limbs. Conduction velocities were slightly below the normal range. Rectal and/or sural nerve biopsy revealed the presence of amyloid deposit. Molecular analysis showed that all patients were heterozygotes for the TTR Met30 mutation. Eleven patients underwent orthotopic liver transplantation (OLTx) from 1993 to 2013. Eight of them showed remarkable improvement especially of their autonomic symptoms and muscle strength. They gained weight and their paresthesias also subsided. Of the operated patients, two died of post-operative complications, one of intracerebral hemorrhage and one of unrelated cause.