Abstract
Acral peeling skin syndrome (APSS), a subvariant of peeling skin syndrome, is a rare autosomal recessive genodermatoses characterized by spontaneous, periodic, painless desquamation of the skin limited to the dorsa of hands and feet. Histologically, skin peeling occurs due to the separation of stratum corneum from stratum granulosum. Here, we describe a case of APSS in association with transgradient palmoplantar keratoderma, with similar history in two younger siblings. Familial acral peeling skin syndrome in association with transgradient palmoplantar keratoderma has not been reported in literature.
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