Abstract

BackgroundFAM83H was originally reported to be essential for dental enamel formation. However, FAM83H has recently been implicated in tumorigenesis and tumor progression. Analysis of a publicly available gene expression database revealed a significant correlation between FAM83H and Nectin1 mRNA expression and bladder urothelial carcinoma (BUC). Therefore, we investigated the association between FAM83H and Nectin1 expression levels and the survival and recurrence of BUC in BUC patients using a tissue microarray.MethodsWe performed immunohistochemical staining of FAM83H and Nectin1 in 165 human BUC tissue sections, and analyzed the prognostic significance of FAM83H and Nectin1 expression.ResultsBoth FAM83H and Nectin1 were mainly expressed in the cytoplasm, and their expression was significantly associated. FAM83H expression was significantly correlated with higher histologic grade, higher T stage, higher TNM stage, and recurrence. Nectin1 expression was significantly associated with higher histologic grade and recurrence. Univariate analysis showed FAM83H expression and Nectin1 expression were significantly associated with worse overall survival (OS) and shorter relapse-free survival (RFS) of BUC patients. In multivariate analysis, levels of FAM83H and Nectin1 were independent indicators of shorter survival of BUC patients.ConclusionsOur results suggest that FAM83H and Nectin1 are important in the progression of BUC, and that expression patterns of these two proteins can be used as prognostic indicators of survival in BUC patients.

Highlights

  • Bladder cancer is a common cancer, accounting for approximately 3.0% of new cancers and 2.1% of cancer deaths worldwide [1]

  • We performed receiver operating characteristic curve analysis according to the death of bladder urothelial carcinoma (BUC) patients to assign patients to FAM83H and Nectin1 negative- and positive expression groups

  • Using these cut-off values, 110 (66.7%) and 101 (61.2%) BUC patients were classified as belonging to the FAM83H positive-group and Nectin1 positive-group, respectively

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Summary

Introduction

Bladder cancer is a common cancer, accounting for approximately 3.0% of new cancers and 2.1% of cancer deaths worldwide [1]. The prognosis of patients with bladder cancer is relatively good, with a 5-year survival rate of approximately 70% [2]. There are two distinct pathways for development of bladder urothelial carcinoma (BUC): a hyperplasia pathway and a dysplasia pathway [5,6,7,8]. The hyperplasia pathway is more common and accounts for 80% of BUCs [6]. Tumors that develop by activation of the hyperplasia pathway first manifest as urothelial hyperplasia with advancement to low-grade papillary urothelial carcinoma [6, 7, 9]. Analysis of a publicly available gene expression database revealed a significant correlation between FAM83H and Nectin mRNA expression and bladder urothelial carcinoma (BUC). We investigated the association between FAM83H and Nectin expression levels and the survival and recurrence of BUC in BUC patients using a tissue microarray

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