Abstract
Glioma represents the most frequently occurring type of primary brain tumor. The FAM83D gene was identified as a mitosis-related gene that plays a critical role in the development and progression of various types of cancer. However, its precise involvement in glioma remains largely unknown. This study aims to investigate the expression and clinicopathological significance of FAM83D and to analyze its potential prognostic value in brain glioma. First, we examined the influence of FAM83D expression on the overall survival (OS) of glioblastoma patients through dataset analysis. The results showed that FAM83D expression levels negatively correlated with OS in Brain Low Grade Glioma (BLGG) patients, but not in glioblastoma multiforme (GBM) patients. Subsequently, we analyzed the levels of FAM83D in the brains of developing mice after birth. We observed that FAM83D transcription was upregulated in mouse glioma cells compared to primary astrocytes, but not microglia cells. Finally, we found that FAM83D levels negatively regulated the growth rate of glioma cells in vitro. Our findings indicate that FAM83D may not promote glioma cell growth in vitro and is not an effective biomarker in glioblastoma diagnosis. Therefore, it is unlikely to be useful as a clinical tool for the detection or monitoring of glioma.
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