Abstract
Reliably diagnosing pregnancy in women presenting with nonspecific abdominal pain can be lifesaving. If diagnostic tests are unreliable, however, valuable time and resources can be wasted pursuing unnecessary and potentially harmful interventions. After four false positive-urine pregnancy tests in one week, we began investigating the laboratory's entire process involving the UPreg tests. We discovered that, as is common in resource-poor settings, the laboratory repeatedly reused test tubes. We found that the false-positive tests resulted from performing the UPreg tests in test tubes that were improperly cleaned and, for the most part, had been used immediately beforehand to test women coming into the maternity ward. Sufficient residua from the pregnant women's high ß-HCG levels had remained in the test tubes to cause subsequent false-positive results in our emergency ward patients. Although pregnancy can now be reliably diagnosed with inexpensive, disposable and simple tests, these tests must not only be used properly, but also, when used in the laboratory, be accompanied by appropriate cleaning and quality-control procedures. This is particularly essential in resource-constrained environments.
Highlights
Diagnosing pregnancy in women presenting with nonspecific abdominal pain can be lifesaving
Several drops of urine were placed on individual pre-packaged one-time use ß-HCG Urine Pregnancy POCT kits of Chinese manufacture, where two lines indicate pregnancy, and one line indicates the absence of pregnancy
As is common in resource-poor settings, the laboratory was reusing test tubes
Summary
Diagnosing pregnancy in women presenting with nonspecific abdominal pain can be lifesaving. Clinicians have used urine tests to verify pregnancies. As far back as 1350 B.C., Egyptians had women urinate on a mixture of wheat and barley seeds, believing that sprouting seedlings would indicate pregnancy (Verification tests in the 1960s found accuracy approaching 70%!). In the middle-age, “piss-prophets” claimed that they could predict pregnancy using the color of a woman’s urine, while in modern times, importance was placed on body temperature, the medical history and the physical examination [1]. These methods, though widely used, were far less reliable than those of the ancient Egyptians
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