Falls From Taking Multiple Medications May Be a Risk for Both Young and Old

Abstract

The primary outcome measures are a score on the Orthostatic Hypotension Symptom Assessment Scale which measures such factors as dizziness, problems with vision, and weakness recorded 30 minutes after the dose is given on day 16 of a patient’s participation in the trial and assessment of syncope or near syncope within 15 minutes of standing, also 30 minutes postdose on day 16. The other trial will enroll 18 individuals in a randomized, doubleblind, placebo-controlled, crossover tilt-table study in which patients lie on a table that adjusts body position from horizontal to vertical to simulate standing up. The primary outcome measure is time to onset of syncope or near syncope while on a tilt table as measured 1 hour postdose. The estimated primary completion date for both trials is May 2014.