Abstract
Cancer Immunology Tumors are adept at escaping immune system surveillance or suppressing immune system activity. Serrels et al. found that focal adhesion kinase (FAK), which is implicated in immune escape mechanisms, activated a transcriptional network that increased interleukin-33 (IL-33) levels in tumor cells. In a mouse model of squamous cell carcinoma, FAK-IL-33 complexes boosted the production and secretion of key immunosuppressive factors. Blocking these FAK-mediated signals may help the immune system find and kill tumors. Sci. Signal. 10 , eaan8355 (2017).
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