Failure to transfer sensitivity to skin homografts by means of "immune" lymphoid cells in diffusion chambers.

Abstract

ALTHOUGH there has been a considerable number of reports dealing with the susceptibility of dissociated cellular homografts of many tissues, notably those derived from the lymphohaematopoietic system, to humoral isoantibodies1, the majority of attempts to demonstrate that humoral factors play any significant part in the destruction of skin and other solid tissue homografts have failed2. Indeed, most of the available evidence sustains the premise that a ‘cellular’ immunity is involved and that the demise of a homograft is causally related to its characteristic infiltration by mononuclear cells.