Abstract
Abstract In the present study, we have investigated the ability of the non-metabolizable tolerogen, 2,4-dinitrophenyl (DNP)-d-glutamic acid-d-lysine (D-GL) to induce tolerance in normal and sensitized guinea pigs to dinitrochlorobenzene (DNCB) contact sensitivity. The data show that treatment with DNP-D-GL, which very efficiently suppresses anti-DNP antibody responses in virgin and primed guinea pigs, does not affect the ability of these animals to develop and to display contact sensitivity to DNCB. These observations confirm the suggestions from earlier studies that important operational differences exist in the induction of tolerance in thymus derived and bone marrow-derived lymphocytes “presumed” to be concerned with the same DNP specificity.
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