FAILURE TO INDUCE GASTRIC ATROPHY IN DOGS BY INJECTION OF INSULIN-STIMULATED AND NOCTURNAL BASAL GASTRIC JUICE.

Abstract

T hE PR~:SENCE in gastric juice of a substance capable of inhibiting gastric secretion when injected intravenously into dogs has been reported several times. 1-4 It has been claimed that multiple injections of dialyzed, lyophilized, normal human gastric juice produced atrophic gastritis and histamine-fast achlorhydria in Heidenhain pouches. 4 A recent study 5 failed, however, to demonstrate any effect of continuous intravenous administration of lyophilized human gastric juice (obtained by histamine st imulat ion)on gastric acid secretion or on the histologic appearance of the gastric mucosa Of dogs. Thus the claim of Smith e t al. 4 that such a procedure regularly produced achlorhydria and atrophic gastritis was not confirmed. Gastric juice obtained by histamine stimulation was found also to have no effect upon the maximal acid output of the fundal pouches when given innnediately prior to the injection of histamine. 5 Furthermore, preparations of gastric juice from nonsecretors with Group O blood and from secretors with Group A, AB, or B blood were alike in the failure to affect secretion and histology. The possibility remained that, in the histamine-stimulated gastric juice which was utilized, a substance capable of promoting gastric mucosal atrophy, or as others have previously found, of inhibiting gastric secretion, was present in an amount insufficient to produce these effects, a We therefore decided to repeat the study, utilizing pooled human gastric juice obtained by continual nocturnal aspiration (Group 1) and by stimulation with intravenous administration of insulin (Group 2).