Abstract
ABSTRACTTwenty warts including Tinea versicolor like lesions of epidermodysplasia verruciformis were examined for cell membrane associated β2 microglobulin by the use of the direct immunofluorescence and indirect immunoperoxidase technique. The human papilloma virus infected keratinocytes in the granular layer and the uppermost stratum spinosum lack immunoreactive β2 microglobulin on the cell surface. This finding indicates that the human papilloma virus does alter the cell membrane properties of the infected target keratinocyte, and the failure to detect β2 microglobulin on cell surface does not necessarily mean that these cells have undergone malignant transformation.
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