Abstract
Urinary excretion of luteinizing hormone releasing factor activity (LRF) in rats was studied by bioassay of urinary extracts collected over a 3-hr period after intravenous injection of porcine stalk median eminence extracts (SME). Although LRF activity of 0.05 SME equivalents added directly to urine was detectable in this assay system, no LRF activity could be detected in one third aliquots of a 3-hr urine collection from animals injected intravenously with ten SME equivalents. These results show that less than 1.5% of the injected dose is excreted in the urine. Since LRF was not detectable in plasma extracts of the rats at 3 hr, it would appear that urinary excretion of this hormone is not involved significantly in its removal from the intravascular space. (Endocrinology 93: 259, 1973)
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