Abstract
Summary Antibody-dependent complement-mediated lysis of a viral-induced lymphoma cell was confined to the G1 phase of the cell cycle. During the portion of the cell cycle in which the cells were resistant to complement-mediated lysis (S, G2, and M), C5 and C8 became bound to the plasma membrane and ultrastructural lesions characteristic of complement membrane attack developed after incubation of the cells with antibody and complement. Quantitative studies revealed that the plasma membrane of cells bound equivalent numbers of C8 molecules in all phases of the cell cycle. These findings emphasize the importance of events occurring subsequent to activation and attachment of the cytolytic effector system for destruction of this tumor cell.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
