Failure of Sulfinpyrazone to Prevent Left Ventricular Thrombosis in Patients with Acute Myocardial Infarction Treated with Oral Anticoagulants: A Randomized Trail in 100 Patients

Abstract

Left ventricular thrombosis (LVT) has been known for a long time as complication of acute myocardial infarction (MI) (Garvin C.F., Hellerstein H.K.). Patients with LVT run a risk for systemic embolism, which can contribute to morbidity and mortality after MI (Visser C.A., 1985, Meltzer R.S.). Previous studies have shown that LVT with subsequent embolism can develop shortly after MI (Eigler N., Weinreicht D). Administration of anti-thrombotic therapy to prevent formation of a LVT should be started in the early phase of MI. Despite early anti-throbotic therapy with oral anticoagulants or heparin, LVT is still found in patients with acute or recent MI (Weinreich D.J., Cokkinos D.V., Scholl J. < Friedman M.J., Gueret P., Ezekowitz M.D. 1984). Two-dimensional echocardigraphy (2 DE) and indium-III platelet scintigraphy (IND) have proven to be valuable and sensitive techniques in identifying LVT (Reeder GS, Stratton J.R., Visser C.A., 1983, Ezekowitz M.D., 1981, 1982, 1983, Asinger R.W., 1981 I, Verheugt F.W.A., Funke Kupper A.J.). 2DE provides anatomical information and detects the thrombus mass. With IND hematological activity at the surface of the thrombus is assessed.