Abstract
SC-19220 has been shown to inhibit some actions of PGE 1 on isolated intestinal muscle and intestinal motility. We studied the effects of this compound on PGE 1-induced inhibition of gastric secretion in pylorus-ligated rats. In equimolar or twice molar amounts, SC-19220 did not affect PGE 1 gastric antisecretory actions. The antagonistic actions of SC-19220 appear to be selective and thus may be of clinical importance.
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