Abstract
Radioprotective drugs such as S-2 [3-Aminopropylamino] Ethylphosphorothioic acid (WR-2721) have been suggested for use to prevent radiation pneumonitis complicating radiotherapy of primary and metastatic tumors of lung, mediastinum, and chest wall. Juvenile female New Zealand White rabbits (R) between 9 and 12 months of age were either given saline or WR-2721 (36.5 mg/Kg) intravenously 15 minutes before irradiation. Low dose R (n=7) received 250 rads × 4 days to the thorax while high dose R (n=7) were given 375 rads × 4 days. Two, four and six weeks after initiating irradiation, animals were killed and pulmonary pressure volume studies performed. No significant differences between treated or control R (n=7) were seen in body weight change, food intake, water consumption, respirations, PaCO2, WBC, Hct, rectal temp, lung weight, lung distensibility, lung compliance, minimal surface tension or histologic changes. Pretreatment with WR-2721 does not seem to protect juvenile rabbit lung from irradiation damage.
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