Abstract
Exogenous globin mRNA or encephalomyocarditis virus mRNA can be efficiently translated by S30 lysates of mouse erythroleukemic cells and also by lysates of similar cells in which hemoglobin synthesis had been induced by dimethylsulfoxide. Cell-free extracts from interferon-treated cells had not only lost their translation capacity for viral but also for globin mRNA. The indiscriminate inhibition of the in vitro translation capacity of natural mRNA often seen in extracts from interferon-treated murine cells seems therefore to be caused by a defect of the cell-free systems. The defect in the S30 lysates of interferon-treated cells could be repaired by the addition of tRNA.
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