Abstract
Inhibition by fusidic acid or siomycin of either crude or highly purified in vitro polypeptide synthesizing systems does not substantially affect the rate or the extent of the reaction of the nascent peptidyl chains with puromycin. Thus, fusidic acid and siomycin seem to freeze peptidyl-tRNA in the ribosomal P-site and to act primarily as inhibitors of aminoacyl-tRNA binding.
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