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Abstract
Injections of clomiphene (3\m=.\0mg/kg) on Days 12, 14, 16 and 18 of pregnancy induced complete resorption of fetuses, a polyfollicular state of the ovary and luteolysis in rats. If reserpine was given at the same time as clomiphene, pregnancy was maintained and the status of the fetuses, placentae, ovaries and corpora lutea resembled that found in control rats. The fetal survival rate (96\m=.\7%)was found to be almost identical with that of the controls (97\m=.\9%).It is suggested that abnormal stimulation of the pituitary FSH and LH may possibly be the primary cause of the clomiphene-induced interruption of pregnancy in
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