Abstract
The ability of breast cancer cells in long-term tissue culture to aromatize androstenedione to estrone and estradiol was examined. ( 3H) androstenedione (1.1 × 10 −7M) was incubated with 9 cell lines of human breast cancer and one line derived froa a dimethylbenz(a)anthracene induced rat mammary tumor. No conversion to estrone or estradiol was detected. The findings are discussed in light of previous studies showing aromatization of androgens in breast cancer tissues.
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