Abstract
Amantadine hydrochloride has been reported efficacious in the symptomatic management of patients with multiple sclerosis (MS). To characterize further the potential effects of amantadine in MS, we studied the drug's effect on immunological parameters in the experimental allergic encephalomyelitis (EAE) model. Nine Lewis rats were used; 3 served as controls and 6 were EAE-induced. Three of the EAE-induced rats received amantadine (AMT) (0.3 g/kg/day) at the onset of EAE symptoms. Sera were collected post-AMT treatment and assayed for antimyelin basic protein antibody (anti-MBP) and 2'3'-cyclic nucleotide 3'-phosphohydrolase activity (CNP). The mean differences in the immunological parameters between treated and nontreated EAE-induced groups were not significant. These findings fail to demonstrate a specific effect of amantadine on immunologic responses tested in the EAE model, and do not support the notion that the effects of amantadine in MS are linked to basic alterations in immune responses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
