Factors underlying impairment on activities of daily living in behavioral variant frontotemporal dementia

Abstract

Event Abstract Back to Event Factors underlying impairment on activities of daily living in behavioral variant frontotemporal dementia J. R. Hodges1, M. Hornberger1, C. M. Kipps2 and E. Mioshi1* 1 Prince of Wales Medical Research Institute, Australia 2 Southampton University NHS Trust, Wessex Neurological Centre, United Kingdom Patients with the behavioral variant of frontotemporal dementia (bvFTD) have marked impairment in everyday life, yet little is known about factors underlying this impairment. Moreover, a recently identified FTD subgroup with normal brain imaging shows an excellent prognosis (phenocopy cases) and their performance on activities of daily living (ADL) tasks is unknown. Eighteen bvFTD patients (phenocopy: n=10; pathological: n=8. Classification was based on atrophy on MRI scans, which were kept blind for the ADL assessment) were assessed on the Assessment of Motor and Process Skills, a standardized performance-based activity of daily living instrument. Apathy, executive dysfunction and disinhibition, as measured by the Frontal Systems Behavioural Scale, carer version (FrSBe), global cognition (Addenbrooke’s Cognitive Examination, ACE-R), and visual MRI brain atrophy were also evaluated. There was a significant association between the ADL measure and the atrophy on the frontal lobes (r= -0.549; p <0.05). Only frontal atrophy on MRI scans explained the variance of ADL scores; no variable measured by the FrSBe entered the regression model. Performance on the ADL assessment could distinguish between phenocopy and pathological patients (78.8%). Although phenocopy and pathological bvFTD patients present with similar symptomatology, performance-based assessment of ADLs can aid in the differential diagnosis of bvFTD. Conference: The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010. Presentation Type: Poster Presentation Topic: Neurorehabilitation Citation: Hodges JR, Hornberger M, Kipps CM and Mioshi E (2010). Factors underlying impairment on activities of daily living in behavioral variant frontotemporal dementia. Conference Abstract: The 20th Annual Rotman Research Institute Conference, The frontal lobes. doi: 10.3389/conf.fnins.2010.14.00127 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Jun 2010; Published Online: 30 Jun 2010. * Correspondence: E. Mioshi, Prince of Wales Medical Research Institute, Sydney, Australia, e.mioshi@powmri.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers J. R Hodges M. Hornberger C. M Kipps E. Mioshi Google J. R Hodges M. Hornberger C. M Kipps E. Mioshi Google Scholar J. R Hodges M. Hornberger C. M Kipps E. Mioshi PubMed J. R Hodges M. Hornberger C. M Kipps E. Mioshi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.