Abstract
Objective:Evaluating the effects of heart cavity volume, presence and absence of perfusion defect, gender and type of study (stress and rest) on the difference of systolic parameters of myocardial perfusion scan in 16 and 8 framing gated SPECT imaging.Methods:Cardiac gated SPECT in both 16 and 8 framing simultaneously and both stress and rest phases at one-day protocol was performed for 50 patients. Data have been reconstructed by filter back projection (FBP) method and left ventricular (LV) systolic parameters were calculated by using QGS software. The effect of some factors such as LV cavity volume, presence and absence of perfusion defect, gender and type of study on data difference between 8 and 16 frames were evaluated.Results:The differences in ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in both stress and rest were statistically significant. Difference in both framing was more in stress for EF and ESV, and was more in rest for EDV. Study type had a significant effect on differences in systolic parameters while gender had a significant effect on differences in EF and ESV in rest between both framings.Conclusion:In conclusion, results of this study revealed that difference of both 16 and 8 frames data in systolic phase were statistically significant and it seems that because of better efficiency of 16 frames, it cannot be replaced by 8 frames. Further well-designed studies are required to verify these findings.
Highlights
Gated SPECT is used for evaluation of left ventricular (LV) systolic and diastolic functions and data are acquired by the electrocardiographic signal using a specific number of interval, from R wave to R wave [1]
It is reported that 8-frame gated SPECT is likely to underestimate the ejection fraction (EF) as compared to other standard modalities like magnetic resonance imaging (MRI) [3,4] or equilibrium radionuclide angiography (ERNA) [5]
It showed that LVEF in gated SPECT underestimates as compared to ERNA and this underestimation reduces by increasing the number of frames
Summary
Gated SPECT is used for evaluation of left ventricular (LV) systolic and diastolic functions and data are acquired by the electrocardiographic signal using a specific number of interval, from R wave to R wave [1].Each image is generated by counts which are accumulated during each of these intervals. It is reported that 8-frame gated SPECT is likely to underestimate the ejection fraction (EF) as compared to other standard modalities like magnetic resonance imaging (MRI) [3,4] or equilibrium radionuclide angiography (ERNA) [5]. Systolic parameters of 8, 16, 32 frames had been compared to results of ERNA. It showed that LVEF in gated SPECT underestimates as compared to ERNA and this underestimation reduces by increasing the number of frames. Vallejo et al [6] showed that in the presence of perfusion defects, quantitative gated SPECT (QGS) overestimated the volume as compared to MRI as a standard modality
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