Abstract
Aim: This study aimed to investigate the relationship between clinicopathological characteristics of atypical meningiomas (AM) and its post-operative recurrence.Materials and Methods: The clinicopathological characteristics and findings from follow up were retrospectively reviewed and compared between AM and benign meningioma (BM) patients. Univariate and multivariate analyses were employed to identify the factors related to the post-operative recurrence of AM.Results: More BM patients were females and received complete resection; the recurrence rate was significantly lower in BM patients as compared to AM patients. The progesterone receptor (PR), E-cadherin protein (E-Ca) and β-catenin positive rates and Ki67 labeling index were significantly different between two groups. Univariate analysis showed the age, tumor size, tumor invasiveness, E-Ca expression, and extent of resection were related to the post-operative recurrence of AM. However, multivariate analysis showed only the extent of resection and tumor invasiveness were the independent factors associated with the post-operative recurrence of AM.Conclusions: The extent of resection and tumor invasiveness are related to the post-operative recurrence of AM. To improve the surgical procedures to maximize the tumor resection is important to improve the prognosis of AM patients.
Highlights
Meningiomas, a tumor of meningothelial cell origin, are the second most common intracranial tumor and account for about 24–30% of intracranial tumors [1,2,3]
We retrospectively investigated 30 patients diagnosed with atypical meningiomas (AM) in two clinical centers, and the clinicopathological characteristics and findings from follow up were collected and compared between AM patients and benign meningioma (BM) patients as controls
30 patients diagnosed with Benign meningiomas (BM) (WHO grade I) and having complete clinical record were included as controls: they were pathologically diagnosed with BM in the same period; they had no severe heart, liver, and liver disease; there was no metastasis; the age ranged from 18 to 80 years
Summary
Meningiomas, a tumor of meningothelial cell origin, are the second most common intracranial tumor and account for about 24–30% of intracranial tumors [1,2,3]. According to the World Health Organization classification system, meningiomas are classified into grade I (typical), grade II (atypical), and grade III (anaplastic) tumors. Most meningiomas are benign (grade I), and atypical meningiomas (AM) account for about 5–7% of meningiomas. The benign meningiomas have a relatively low risk of recurrence (∼10%) after complete resection, but AM and anaplastic meningiomas are characteristically more aggressive in nature and associated with higher recurrence risks (29–52% and 50–94%, respectively) [4]. Benign meningiomas (BM) seem to be related to estrogen levels and are more common in women, but AM and anaplastic meningiomas are more common
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