Factors Promoting Alkene Migratory Insertion into Metal-nitrogen Bond During Hydroamination in Recent Studies

Abstract

: Migratory insertion is a fundamental organometallic transformation that enables the functionalization of an unsaturated bond. Recent reports on catalytic hydroamination provide evidence that supports an intermolecular migratory insertion pathway featuring alkene insertion into metalnitrogen (M-N) bonds. This article presents factors influencing the rate of migratory insertion in latetransition metal-catalyzed hydroamination, including steric and electronic effects from ligands, alkenes, and metal centers, along with stabilization from coordinated amine intermediates and ordered transition states.