Factors of Impact on Graft Function at 2 Years After Transplantation in Living-Donor Kidney Transplantation: A Single-Center Study in China

Abstract

Objective The aim was to investigate the factors that affect graft function at 2 years after transplantation in living related–donor kidney transplantation. Methods We retrospectively reviewed the clinical data of 144 patients who underwent living related–donor kidney transplantation in our hospital from December 2005 to December 2008. Recipients were divided into 2 groups according to glomerular filtration rate (GFR) at 2 years after transplantation: ≤60 mL/min/1.73 m 2 (n = 51) and >60 mL/min/1.73 m 2 (n = 93). Variables which affected graft function were compared between the groups. The significant factors were analyzed using logistic regression. Results Univariate analysis showed significant differences for donor age, donor GFR, recipient weight, recipient body mass index, donor-to-recipient body weight ratio, and acute rejection episodes ( P < .05). Logistic regression analysis revealed the independent factors affecting renal function at 2 years after transplantation to be donor GFR (β = 0.032; odds ratio [OR] 1.032; P = .004) and recipient body weight (β = −0.069; OR 0.934; P = .001). Receiver operating characteristic (ROC) curve analysis showed cutoff values of donor GFR and recipient body weight to be >111.25 mL/min/1.73 m 2, and ≤67 kg, respectively. Areas under the ROC curve of donor GFR and recipient body weight were 0.612 and 0.665, respectively. Sensitivity and specificity of donor GFR were 43.0% and 78.4%, respectively. Sensitivity and specificity of recipient body weight were 82.8% and 45.1%, respectively. Conclusions Donor GFR and recipient body weight were the independent factors effecting renal function at 2 years after transplantation.