Factors of Delayed Hyperperfusion and the Importance of Repeated Cerebral Blood Flow Evaluation for Hyperperfusion After Direct Bypass for Moyamoya Disease

Abstract

Postoperative hyperperfusion is an important complication after direct bypass for moyamoya disease, which sometimes occurs late after initial postoperative cerebral blood flow (CBF) measurement. This study aimed to clarify the incidence of hyperperfusion with management using postoperative continuous sedation and repeated postoperative CBF measurement and to identify factors associated with delayed hyperperfusion. This retrospective study evaluated 72 consecutive hemispheres in 56 adult Japanese patients with moyamoya disease who underwent direct bypass. Postoperative continuous sedation was routinely administered based on CBF evaluation. First, the incidence of symptomatic hyperperfusion was investigated. Second, radiologic hyperperfusion (RHP), which was strictly defined as >30% increase in CBF compared with the contralateral side, and factors associated with delayed RHP were statistically analyzed. Postoperative symptomatic hyperperfusion occurred in 3 hemispheres (4.2%), including subarachnoid hemorrhage in 1 hemisphere (1.4%). RHP immediately after surgery was identified in 16 hemispheres (22.2%). In 8 hemispheres (11.1%), RHP appeared or worsened several days after initial CBF study. In univariate logistic regression analysis, decreased preoperative cerebral vasoreactivity was significantly associated with delayed RHP. The incidence of symptomatic hyperperfusion was 4.2% with management. Delayed hyperperfusion was significantly associated with decreased cerebral vasoreactivity. Therefore, repeated CBF measurements evaluating preoperative cerebral vasoreactivity may decrease complications.