Factors of Anxiety-Affective Symptoms Persistence in Depressions of Various Origins

Abstract

The aim of study: the current study has been caried out in order to find the anxiety-affective symptomatology persistence duration (AASPD) under standard antidepressants therapy and its neurobiological and premorbid personality predictors in different diagnostic groups.Patients and methods: 191 patients were included into study. Among them 57 patients with organic anxiety affective disorder (OAAD), 41 with endogenous depression (ED), 14 with anxiety neurotic disorder (AND) and 93 with schizophrenia. The Munich personality test and Toronto alexithymia scale were used for assessment of premorbid personality, while SCL-90 and MMSE — for the assessment of psychopathology structure. For the assessment of handedness Annett scale has been used. The product moment correlation analysis was performed for the assessment of relationships between premorbid personality, MMSE and Annett scale score and psychopathology persistence.Results: the symptomatology persistence was maximal in OAAD (21.37 ± 8.33) and smallest in ED (16.27 ± 4.38). Neuroticism correlated positively with AASPD in ED (r = 0.481; р = 0.001). Duration of disorder correlated positively with AASPD (r = 0,286; p = 0.031), while MMSE correlated negatively (r = –0.267; p = 0.045) in OAAD. In AND the negative correlation between MMSE and AASPD (r = –0.585; p = 0.028) and between Annett score and AASPD (r = –0.617; p = 0.032). No stochastically significant correlations were revealed in schizophrenia.Conclusion: the data obtained are important both for further study of the pathogenesis of these disorders and for the prediction and prevention of affective disorders in clinical practice.