Abstract

Vaccine hesitancy has become a significant issue. We aimed to elucidate the factors influencing vaccine hesitation in Chinese residents and to analyze and recommend promotional strategies and measures. In total, 92 Chinese residents from 10 provinces were interviewed using semi-structured face-to-face interviews following a predetermined survey framework in this qualitative study. We found trust in vaccine safety, access to professional advice, and vaccine price and effectiveness to be the main factors influencing vaccine hesitation. Additionally, residents in areas with a higher per capita GDP tend to receive more social support, believe that vaccination is beneficial and can prevent diseases, pay more attention to whether the vaccine is safe and has undergone various clinical trials, and are more likely to seek advice from individuals with vaccination experience as opposed to their counterparts in areas with a lower per capita GDP. Notably, as per capita GDP rises, individuals become more concerned about the price of vaccines. Measures such as clarifying vaccine safety and effectiveness, reducing self-funded vaccine prices, offering free vaccination for special groups, strengthening the publicity role of medical staff, and taking advantage of network platforms are essential to reduce vaccine hesitancy among Chinese residents.

Highlights

  • As of 16 September 2021, there have been more than 22.6 million confirmed cases of coronavirus disease (COVID-19) globally, including 4.6 million deaths [1]

  • The COVID-19 pandemic poses tremendous challenges to human health, and the long-term effects of transmission-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which affects a variety of industries, are attracting great attention worldwide

  • The summary of factors influencing vaccine hesitancy in China was shown in Figure 1 and Supplementary Table S1

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Summary

Introduction

As of 16 September 2021, there have been more than 22.6 million confirmed cases of coronavirus disease (COVID-19) globally, including 4.6 million deaths [1]. The COVID-19 pandemic poses tremendous challenges to human health, and the long-term effects of transmission-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which affects a variety of industries, are attracting great attention worldwide. Based on the successful stories of smallpox eradication achieved by means of the vaccinia vaccine [2], heavy expectations have been placed on vaccines to suppress the COVID19 pandemic. COVID-19 vaccines have been developed [3], its application in some countries is not promising [4,5]. Vaccine-preventable diseases have been resurging owing to the ever-growing anti-vaccination movement [6].

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