Abstract
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord blood unit groups (P < 0.001 for all). No cord blood units were discarded owing to contamination-related issues. The mean gestational age for pregnant women whose umbilical cord blood was stored was 36.6 ± 1.0 weeks. Conclusion: Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were significantly different between the eligible and discarded cord blood unit groups. The low rate of specimen storage was most likely because of the unique characteristics of perinatal medicine patients. Physicians should choose appropriate donors for cord blood collection to increase the rate of cord blood utilization.
Highlights
Umbilical cord blood (CB) is a natural source of hematopoietic stem cells (HSCs) and is an accepted alternative to bone marrow for transplantation purposes in a variety of diseases such as leukemia, congenital immunodeficiencies, hereditary metabolic disorders, hemoglobinopathies, and bone marrow failure syndromes [1,2,3,4]
Private CB banks (CBBs) are profit-oriented institutions facilitating the collection and storage of CB from families on demand, for future autologous or family use, for a certain price [9]. Both public and private CB units (CBUs) can be used for directed banking, which is aimed at using stored sibling donor CB for family members when a first-degree relative is diagnosed as having a disease that can be cured using CB transplantation [10]
The maternal characteristics, neonatal characteristics, and CBU parameters of the donors in terms of mean, standard deviation, minimum–maximum values, and P-values are shown in the Table for the indicated groups
Summary
Umbilical cord blood (CB) is a natural source of hematopoietic stem cells (HSCs) and is an accepted alternative to bone marrow for transplantation purposes in a variety of diseases such as leukemia, congenital immunodeficiencies, hereditary metabolic disorders, hemoglobinopathies, and bone marrow failure syndromes [1,2,3,4]. Public banks collect altruistic CBUs and process, store, and release the product for clinical programs. Private CBBs are profit-oriented institutions facilitating the collection and storage of CB from families on demand, for future autologous or family use, for a certain price [9]. Both public and private CBUs can be used for directed banking, which is aimed at using stored sibling donor CB for family members when a first-degree relative is diagnosed as having a disease that can be cured using CB transplantation [10]. A high percentage of CB used clinically is released through public banks, where storage of high-quality CB is ensured by both national and international standards
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