Abstract
Background Although the relationship between gout and cardiovascular has been well demonstrated, there is little information about the difference between gout with cerebrovascular disease and cardiovascular disease. In this study, the differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study. Method The patients from Jiangxi Provincial People's Hospital with gout+CHD, gout+CI, and gout with coronary heart disease and cerebral infarction (gout+CHD+CI) between 2016 and 2020 were included in this study, and the medical record data were collected and analyzed. Results We observed significant differences in age, drinking, hypertension, long-term use of diuretics and NSAIDs, sUA, CRE, and blood glucose in patients with gout+CHD and gout+CI. The sUA level was significantly positively correlated with smoking, CRE, and TG in the gout+CI group and was only positively correlated with CRE in the gout+CHD group and the gout+CHD+CI group (p < 0.05). Interestingly, the sUA level was only negatively correlated with the age and gender in the gout+CI group (p < 0.05). After excluding factors with no significant statistical effect, only age, gender, smoking, CRE, and TG were included in the multiple linear regression model. It suggested that smoking, CRE, and TG are positively correlated with the sUA level, while age was negatively correlated with the sUA level. Conclusions There are many discrepancies in clinical characteristics between gout+CHD patients and gout+CI patients, especially that the factors that affect UA levels are significantly different. The data also suggested that uric acid-lowering therapy may need to be strengthened in the young gout+CI patients with a history of smoking.
Highlights
Gout is a chronic inflammatory disease, which was caused by abnormal purine metabolism and decreased uric acid excretion leading to increased levels of serum uric acid (sUA)
The information was collected from 3464 patients with gout from January 1, 2016, to November 1, 2020, which included 626 gout+CHD patients, 584 gout with cerebral infarction (gout+cerebral infarction (CI)) patients, and 151 gout+CHD+CI patients
We conducted a cross-sectional study on the gout +CHD group, gout+CI group, and gout+CHD+CI patients to explore the characteristics of gout+CI patients and the factors that affect uric acid in these patients
Summary
Gout is a chronic inflammatory disease, which was caused by abnormal purine metabolism and decreased uric acid excretion leading to increased levels of sUA. Increased levels of sUA have been shown to be associated with increased risk of cerebral infarction (CI) [6, 7], there are few data on the influencing factors of sUA levels in patients with gout and CI. The differences between gout with cerebral infarction (gout+CI) and gout with coronary heart disease (gout+CHD) and related factors that affect serum uric acid (sUA) levels in gout+CI were investigated by a cross-sectional study. After excluding factors with no significant statistical effect, only age, gender, smoking, CRE, and TG were included in the multiple linear regression model It suggested that smoking, CRE, and TG are positively correlated with the sUA level, while age was negatively correlated with the sUA level. The data suggested that uric acid-lowering therapy may need to be strengthened in the young gout+CI patients with a history of smoking
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