Abstract
SummaryAntibacterial compounds, including penicillin G and phthalylsulfathiazole or a combination of these drugs produced variable suppression of urinary trimethylamine (TTMA) and indican output in normal male subjects. Three men with rapid intestinal transit time and low initial indican values exhibited markedly reduced TTMA and indican excretion in response to either drug alone and prolonged depression with combined drug treatment; while four men with prolonged intestinal transit time and high initial indican values showed less suppression of TTMA and indican excretion with sulfa or penicillin G alone and only transient suppression of indican and TTMA with combined treatment. It has been concluded that intestinal stasis is a major determinant of the escape of intestinal microflora from the action of these drugs.
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