Abstract
BackgroundThe length of hospital stay is the duration of hospitalization, which reflects disease severity and resource utilization indirectly. Generally, tuberculosis is considered an ambulatory disease that could be treated at DOTs clinics; however, admission remains an essential component for patients’ clinical stabilization. Hence, this study aimed to identify factors influencing hospital stay length during the intensive phase of multidrug-resistant tuberculosis treatment.MethodsA retrospective follow-up study was conducted at three hospitals, namely the University of Gondar comprehensive specialized, Borumeda, and Debremarkos referral hospitals from September 2010 to December 2016 (n = 432). Data extracted from hospital admission/discharge logbooks and individual patient medical charts. A binary logistic regression analysis was used to identify factors associated with more extended hospital stays during the intensive phase of multidrug-resistant tuberculosis treatment.ResultMost patients (93.5%) had a pulmonary form of multidrug-resistant tuberculosis and 26.2% had /TB/HIV co-infections. The median length of hospital stays was 62 (interquartile range from 36 to 100) days. The pulmonary form of tuberculosis (Adjusted odds ratio [AOR], 3.47, 95% confidence interval [CI]; 1.31 to 9.16), bedridden functional status (AOR = 2.88, 95%CI; 1.29 to 6.43), and adverse drug effects (AOR = 2.11, 95%CI; 1.35 to 3.30) were factors associated with extended hospital stays.ConclusionThis study revealed that the length of hospital-stay differed significantly between the hospitals. The pulmonary form of tuberculosis decreased functional status at admission and reported adverse drug reactions were determinants of more extended hospital stays. These underscore the importance of early case detection and prompt treatment of adverse drug effects.
Highlights
The length of hospital stay is the duration of hospitalization, which reflects disease severity and resource utilization indirectly
The pulmonary form of tuberculosis decreased functional status at admission and reported adverse drug reactions were determinants of more extended hospital stays. These underscore the importance of early case detection and prompt treatment of adverse drug effects
This study aimed to determine the length of hospital stay and identify factors associated with extended hospital stays during MDR-TB treatment
Summary
The length of hospital stay is the duration of hospitalization, which reflects disease severity and resource utilization indirectly. This study aimed to identify factors influencing hospital stay length during the intensive phase of multidrug-resistant tuberculosis treatment. According to the 2019 World Health Organization (WHO) report, there were about 484, 00 incident cases of MDR/RR-TB and 214, 000 deaths from MDR/RR-TB [5]. Thirty high burden countries carry more than 85% of the world’s drug-resistant tuberculosis (DR-TB) cases [6]. Ethiopia ranked third amongst the high burden countries in Africa, with an estimated 2100 MDR-TB cases annually [7]. The incidence of susceptible TB was an estimated 165 cases per 100,000 population and ranked 3rd in Africa and 11th in the world, according to the 2019 global TB report [5]
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