Factors Influencing the Five-Year Recurrence of Liver Carcinoma after Surgery

Abstract

Background: Liver carcinoma is a leading cause of death. Most liver cancers (90%) are hepatocellular carcinoma (HCC), and 10% are cholangiocarcinoma (CCA). Although hepatectomy is the treatment of choice for early stage cancer, the 5-year recurrence rates for HCC and CCA have been reported as 73.4% and 82%, respectively. Objective: To identify risk factors for 5-year tumor recurrence and the correlation after resection of liver carcinoma. Materials and Methods: The frequency of recurrence and corresponding risk factors were investigated in patients with HCC and CCA. Data were analyzed using Fisher’s exact test and Cox proportion-hazards model. Results: The present study included 33 HCC and 43 CCA patients (22:11 and 25:18 male:female, 58.0±12.8 and 56.8±8.0 years, respectively). The tumor recurrence rate was 17 (51.5%) and 24 (55.8%) in HCC and CCA patients, respectively. Conclusion: Vascular invasion was a substantial risk factor for tumor recurrence after complete resection in patients with HCC, whereas serum CA19-9 and vascular invasion were the meaningful risk factors of CCA. Keywords: Hepatocellular carcinoma, Cholangiocarcinoma, Recurrence