Abstract
It has been shown by radioimmunoassay that small amounts of metallothionein (MT) are present in blood plasma and cells of normal rats. Concentrations in plasma generally increase after induction of tissue MT synthesis but little is known of the effects of nutritional and physiological factors on the occurrence of MT-I in blood cells or on its distribution among sub-populations of cells. As part of an investigation into the use of MT assays for the assessment of trace element status, we have examined the effects of zinc deficiency, of zinc and cadmium injection, of endotoxaemia and of induced reticulocytosis on the occurrence of MT-I in blood cells of rats.
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