Factors influencing renin diuresis and proteinuria.

Abstract

Summary1. Administration of renin elicits increases in urine flow and urine protein in rats; these phenomena are closely associated; both are impaired by adrenalectomy or hypophysectomy and restored, after adrenalectomy, by replacement therapy; under the experimental conditions neither somatotrophin nor ACTH could be shown to restore the impaired renin responses of hypophysectomized rats. 2. The two different renin preparations used were more effective in stimulating urine flow and proteinuria when given subcutaneous-ly than when given intraperitoneally. 3. Subtotal hepatectomy impaired these responses to injected renin. 4. The administration of sodium potentiates the diuretic and proteinuric effects of injected renin. 5. These responses can be paralleled by appropriate intraperitoneal administration of angiotonin.