Abstract
The way in which luteinizing hormone (LH) and follicle stimulating h ormone (FSH) are related to pituitary glycogen metabolism is investigated by measuring pituitary glycogen content and the activity of glycogen synthetase and glycogen phosphorylase in LH-releasing hormone (LH-RH) treated rat pituitaries. The presence of LH-RH (15 ng/flask) resulted in a significant (p less than .05) release of LH and FSH after 4 hours of incubation. Pituitary LH content was also raised (p less than .05). 3 ng of LH-RH increased pituitary cyclic adenosine monophosphate (AMP) content by 475% in 10 minutes of incubation. Glycogen phosphorylase was converted to its active form with 1-10 ng LH-RH per flask; this glycogenolytic activity occurred within 5 minutes (p less than .01) and was also induced by cyclic AMP in the presence of theophylline. The forms of glycogen synthetase did not appear to be affected by LH-RH or cyclic AMP. It is concluded that pituitary glycogen may be an energy source for release of gonadotropins via LH-RH.
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