Factors for postoperative recurrence of orbital solitary fibrous tumor: an analysis of long\u2010term clinical follow\u2010up results from a Chinese tertiary hospital

Peng Yang,E Qiu,Jun Kang,Hong-Gang Liu,Jia-Liang Zhang,Wei Wang,Li-Bin Jiang,Hao-Cheng Liu

doi:10.1186/s12886-021-01825-6

Peng Yang, E Qiu + Show 6 more

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https://doi.org/10.1186/s12886-021-01825-6

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Abstract

BackgroundThis study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease.MethodsThe clinical data of 16 patients with OSFT treated in our center from 2003 to 2020 were analyzed retrospectively, and the clinical symptoms, treatment methods, and follow-up results were recorded.ResultsOf the 16 patients, 8 were females (50.0 %) and 8 were males (50.0 %); the average age of treatment was 37 ± 7 years and the median follow-up time was 74 (8, 228) months. Sixteen patients with OSFT underwent a total of 29 operations, of which 12 were transorbital approach operations and 17 were transfronto-orbital approach operations. Ten patients (10/16, 62.5 %) had recurrence. The recurrence rate of transorbital approach operations was 83.3 % (10/12), and the recurrence rate of transfronto-orbital approach operations was 17.6 % (3/17). No patients had treatment-related complications.ConclusionsThe main pathological feature of OSFT is a benign tumor. OSFT has a tendency to grow toward the cranio-orbital junction. The postoperative recurrence rate of OSFT is relatively high, so complete tumor resection is very important for prognosis. Inappropriate surgical approaches can lead to incomplete removal of the tumor and cause recurrence. Choosing the correct operation approach according to the position of the OSFT in the orbit and complete removal of the dura mater and bone affected by the tumor is crucial for the prognosis. Nevertheless, regular long-term follow-up after complete resection is necessary.

Highlights

This study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease
We reported the 16 cases of OSFT, with clinical features, imaging manifestations, histopathology, and immunohistochemistry, compared with different prognostic results brought by different surgical approaches
For tumors located in the superficial orbital region, the transorbital approach was used for resection; for patients with tumors located in the cranio-orbital region adjacent to the cavernous sinus invading the intracranial structure or recurring after transorbital approach operation, the transcranial approach operation would be adopted

Summary

Introduction

This study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease. More and more neurosurgeons and ophthalmologists recognized and reported such tumor [4,5,6,7,8], SFT tumor is extremely rare in the orbit. OSFT has been reported in many pieces of literatures, but there are still many differences in tumor recurrence [12]. When the location of the tumor is not suitable for the operation of the ophthalmologist, an improper surgical approach may bring the possibility of tumor recurrence. We reported the 16 cases of OSFT, with clinical features, imaging manifestations, histopathology, and immunohistochemistry, compared with different prognostic results brought by different surgical approaches

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Conclusion