Abstract
BackgroundTo investigate predictors of pathological invasiveness and prognosis of lung adenocarcinoma in patients with pure ground-glass nodules (pGGNs).MethodsClinical and computed tomography (CT) features of invasive adenocarcinomas (IACs) and pre-IACs were retrospectively compared in 641 consecutive patients with pGGNs and confirmed lung adenocarcinomas who had undergone postoperative CT follow-up. Potential predictors of prognosis were investigated in these patients.ResultsOf 659 pGGNs in 641 patients, 258 (39.1%) were adenocarcinomas in situ, 265 (40.2%) were minimally invasive adenocarcinomas, and 136 (20.6%) were IACs. Respective optimal cutoffs for age, serum carcinoembryonic antigen concentration, maximal diameter, mean diameter, and CT density for distinguishing pre-IACs from IACs were 53 years, 2.19 ng/mL, 10.78 mm, 10.09 mm, and − 582.28 Hounsfield units (HU). Univariable analysis indicated that sex, age, maximal diameter, mean diameter, CT density, and spiculation were significant predictors of lung IAC. In multivariable analysis age, maximal diameter, and CT density were significant predictors of lung IAC. During a median follow-up of 41 months no pGGN IACs recurred.ConclusionspGGNs may be lung IACs, especially in patients aged > 55 years with lesions that are > 1 cm in diameter and exhibit CT density > − 600 HU. pGGN IACs of < 3 cm in diameter have good post-resection prognoses.
Highlights
To investigate predictors of pathological invasiveness and prognosis of lung adenocarcinoma in patients with pure ground-glass nodules
The use of computed tomography (CT) to screen for lung cancer has resulted in detection of an increasing number of pure ground-glass nodules (pGGNs) [1], which are consistently found to constitute precursors of lung invasive adenocarcinomas (IACs). pGGNs include atypical adenomatous hyperplasia
There were no significant differences in carcinoembryonic antigen (CEA) concentration (p = 0.792), or the frequencies of pleural retraction (p = 0.857), air bronchogram signs (p = 1.000), or bubble lucency signs (p = 0.598) between the pre-IAC and IAC groups
Summary
To investigate predictors of pathological invasiveness and prognosis of lung adenocarcinoma in patients with pure ground-glass nodules (pGGNs). In computed tomography (CT) images pure groundglass nodules (pGGNs) are visualized as homogeneous hazy lesions of the lung in which the vascular and bronchial components are preserved and there is no solid component. The use of CT to screen for lung cancer has resulted in detection of an increasing number of pGGNs [1], which are consistently found to constitute precursors of lung invasive adenocarcinomas (IACs). PGGNs include atypical adenomatous hyperplasia, Yang et al Radiation Oncology (2020) 15:186 The use of CT to screen for lung cancer has resulted in detection of an increasing number of pGGNs [1], which are consistently found to constitute precursors of lung invasive adenocarcinomas (IACs). pGGNs include atypical adenomatous hyperplasia, Yang et al Radiation Oncology (2020) 15:186
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
