Abstract
AbstractZinc is an element essential to all forms of life. It can play a predominantly catalytic role or a exclusively structural role in proteins. Here, we provide an overview of important structural and catalytic Zn metalloproteins and highlight the key features distinguishing structural Zn sites from catalytic Zn sites. We elucidate why Zn can assume dual roles in proteins and provide ways to distinguish catalytic Zn sites from structural Zn sites and guidelines for targeting these Zn sites in drug target proteins. We also elucidate why the Zn‐bound cysteines in certain structural Zn‐sites are reactive and how they may be distinguished from inert Zn‐bound cysteines.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
