FACTORS ASSOCIATED WITH THE PRESENCE OF CHRONIC MITRAL REGURGITATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Abstract

Aim. T o study the frequency of mitral regurgitation (MR) detection and the factors associated with its presence in patients with stable coronary heart disease. Methods. 874 patients with coronary artery disease undergoing preoperative assessment before elective surgical repair of coronary artery disease, carotid artery disease, atherosclerotic lesions of abdominal aorta and lower extremity arteries were included in the study. All patients were enrolled into three groups depending on the presence and severity of mitral regurgitation: Group 1 patients without mitral regurgitation (n = 448), Group 2 – patients with grade I mitral regurgitation (n = 378), Group 3 – patients with grade II-IV mitral regurgitation (n = 48). Results. The independent predictors of grade II-IV mitral regurgitation according to the multivariate analysis included prior myocardial infarction (p = 0.044), left ventricular aneurysm (p = 0.004), elevated left ventricular end-systolic volume (p<0.001), an increased risk by the EuroSCORE scale (p = 0.004), female gender, the presence of heart failure and angina pectoris. Conclusion. Mild mitral regurgitation was found in 43.2% of patients with stable coronary artery disease, whereas moderate and severe mitral regurgitation in 5.5% of patients. Independent factors associated with the presence of moderate and severe mitral regurgitation included prior myocardial infarction, left ventricular aneurysm, elevated left ventricular end-systolic volume, the presence of chronic heart failure and angina pectoris, female gender. However, there were no relationships between moderate and severe mitral regurgitation and the localization of coronary stenoses.