Abstract
Patients with major depressive disorder (MDD) show hypoactive amygdala responses to positive stimuli. By providing real-time fMRI neurofeedback regarding amygdala activity, patients with MDD are able to increase their amygdala response during positive memory recall, resulting in significant symptom improvement. However, approximately 30% of participants are unable to increase their amygdala response with training. Here, we combine data from multiple experiments to examine whether certain factors are related to neurofeedback learning success.
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