Abstract
Severe fever with thrombocytopenia syndrome (SFTS) is emerging in China and the incidence increased year by year. In this study, we conducted case control study to explore factors associated with SFTS virus (SFTSV) infection and fatal outcome. In the study of factors associated with SFTSV infection, a total of 216 individuals participated the study, including 72 cases and 144 matched controls. There were significant differences in proportion of history of tick bite and breeding domestic animals between cases and controls. Of note, individuals who were unclear whether they had been bitten by ticks had the highest risk of SFTSV infection and odds ratio (OR) was 10.222. In the study of factors associated with SFTS fatal outcome, a total of 129 cases participated the study including 16 deaths and 113 survivors. Significant differences were observed in body mass index (BMI), intervals from illness onset to confirmation, and proportion of gingival hemorrhage between deaths and survivors, whose ORs of these factors were 3.903, 1.996, and 3.826, respectively. Our results suggest that all patients with fever, thrombocytopenia and leukocytopenia in SFTS endemic areas should be suspected of SFTS, even they don’t have history of tick bite, and more intense treatment should be administered to patients with abnormal BMI before laboratory parameters are detected.
Highlights
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease which is caused by SFTS virus (SFTSV), a novel member of the Phlebovirus genus in the Bunyaviridae family[1,2]
Many people lived in similar environments with cases and why other people were not infected with SFTSV? In order to explore further risk factors for SFTSV infection, we selected controls from villages where cases occurred in our study
Individuals who were unclear whether they had been bitten by ticks had the highest risk of SFTSV infection and odds ratio (OR) was 10.222
Summary
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease which is caused by SFTS virus (SFTSV), a novel member of the Phlebovirus genus in the Bunyaviridae family[1,2]. In 2011, a study on risk factors for SFTSV infection was conducted in Henan Province, Hubei Province, and Shandong Province. They reported that farmers were more common among cases and tick bites, cat or cattle ownership and presence of weeds and shrubs in the working environment were risk factors[16]. In order to explore further risk factors for SFTSV infection, we selected controls from villages where cases occurred in our study. Several previous studies reported that some laboratory parameters and clinical symptoms were associated with SFTS fatal outcome. Clinical symptoms associated with fatal outcome were analyzed and other risk factors which can be identified when cases were admitted were analyzed
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