FACTORS ASSOCIATED WITH RECURRENT PREGNANCY LOSS IN THE SUBARCTIC REGION: A LITERATURE REVIEW

Abstract

Mortality rate in the Russian Federation in 2018 exceeded the birth rate again. At the same time, a stable and high frequency of early reproductive losses was noted. Every fifth wanted pregnancy terminates spontaneously before the due date. Living in the subarctic zone is associated with several unfavorable climatic factors. Implementation of the reproductive function in these conditions is influenced by region-specific factors, which have multiple effects on the mechanisms of recurrent pregnancy loss. The literature search was performed using PubMed, Medline, Cyberleninka, Scopus and HAC databases. Assessing the degree of adaptation of women of reproductive age living in the subarctic zone of the Russian Federation helps to assess their psychosomatic status and heart rate variability. Taking into account the adaptation parameters, certain patterns were revealed for women of reproductive age, as well as for each trimester of a normal and pathologically ongoing pregnancy. Particular attention in the assessment of adaptive resources of the body deserve leukocyte indices, by changing the parameters of which it is possible to make a forecast of the ongoing pregnancy. The results of this review are of interest to the clinicians working in the subarctic zone of Russia from the standpoint of personalized approach to prevention and prediction of recurrent pregnancy loss.