Abstract
BackgroundWomen with severe pre-eclampsia/eclampsia are at risk of developing chronic hypertension in future. Chronic hypertension may manifest initially as persistent hypertension at the end of the puerperium. The objective was to determine the incidence and maternal biochemical, hematological and socio-demographic risk factors for persistent hypertension in patients with pre-eclampsia/eclampsia.MethodsThis was a prospective cohort study conducted from November 2008 to May 2009 at Mulago hospital labor ward and postnatal clinic. Participants were 200 women managed for pre-eclampsia/eclampsia and followed up to the end of the puerperium. Data was collected through using pre-coded interviewer-administered questionnaires, checking medical records and laboratory investigations. STATA (release 9) software was used for data analysis. At bivariate analysis, the relative risk of persistent hypertension was estimated at the 95% confidence level. Using multivariate logistic regression analysis, factors that were independently associated with persistent hypertension were evaluated.ResultsFifty four (27.7%) out of the total 195 women had persistent hypertension after puerperium. Serum creatinine and the age of the patient were the only factors associated with persistence of hypertension after puerperium.ConclusionNearly every one in four mothers with pre-eclampsia/eclampsia are at risk of persistent hypertension after the puerperium. Serum creatinine, serum uric acid and participants' age were the only factors independently associated with persistence of hypertension after the puerperium.
Highlights
Women with severe pre-eclampsia/eclampsia are at risk of developing chronic hypertension in future
The hypertension and proteinuria due to pre-eclampsia/eclampsia resolve within six weeks, and women having persistent hypertension and proteinuria thereafter may have an underlying cause
The objective of the study was to evaluate the incidence and factors associated with persistent hypertension in patients that present with pre-eclampsia/eclampsia
Summary
Women with severe pre-eclampsia/eclampsia are at risk of developing chronic hypertension in future. The objective was to determine the incidence and maternal biochemical, hematological and socio-demographic risk factors for persistent hypertension in patients with pre-eclampsia/eclampsia. Pre-eclampsia is an idiopathic multi-system disorder specific to pregnancy It is characterized by hypertension (a blood pressure of higher of 140/90 mmHg or higher in a previously normotensive women) and proteinuria. Pre-eclampsia and eclampsia complicate about 6-8% all pregnancies worldwide [1] and are associated with increased maternal morbidity and mortality. They are associated with development of chronic hypertension [2] as well as cardiovascular and renal complications later in life. The objective of the study was to evaluate the incidence and factors associated with persistent hypertension in patients that present with pre-eclampsia/eclampsia
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