Abstract
BackgroundThe aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS).MethodsA total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined.ResultsIn a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049).ConclusionsOcular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.
Highlights
The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome
The laboratory findings and oral parameters of all 82 patients are summarized in Table 2: 77.2 % of the patients were positive for anti-Sjögren's-syndrome-related antigen A (SSA)/Ro, 38.6 % were positive for anti-Sjögren's-syndromerelated antigen B (SSB)/La, and the proportion of both positive were 41.5 %. 63.4 % were positive for antinuclear antibody (ANA), and 43.8 % were positive for rheumatoid factor (RF)
The ocular surface parameters and keratographic parameters of the 82 patients are summarized in Table 3: the mean ocular staining score (OSS) was 7.65 ± 5.06
Summary
The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Dry eye disease (DED) is a multifactorial ocular surface disease characterized by a loss of tear film homeostasis [1, 2]. In the 2017 Tear Film and Ocular Surface society (TFOS) Dry Eye Workshop (DEWS) II report, DED was classified into aqueous deficient dry eye (ADDE) and evaporative dry eye. Th1- and Th17-associated cytokines, IFN-γ, and IL-17, are all associated with increased inflammation and glandular dysfunction, and IL-1 suppress lacrimal acinar secretion [7,8,9]. This inflammation involves the extragland, which causes symptoms of pain, myalgia, and inflammation of the joint, vascular system, skin, lungs, and kidneys [10]. When SS occurs by itself, it is referred to as pSS, and when accompanied by another autoimmune disease, it is referred to as secondary
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
