Abstract
OBJECTIVESTuberculosis (TB) is a global public health problem that causes morbidity and mortality in millions of people per year. The purpose of this study was to examine the relationship of potential risk factors with TB mortality in Iran.METHODSThis cross-sectional study was performed on 9,151 patients with TB from March 2017 to March 2018 in Iran. Data were gathered from all 429 counties of Iran by the Ministry of Health and Medical Education and Statistical Center of Iran. In this study, a generalized estimating equation-based zero-inflated negative binomial model was used to determine the effect of related factors on TB mortality at the community level. For data analysis, R version 3.4.2 was used with the relevant packages.RESULTSThe risk of mortality from TB was found to increase with the unemployment rate (=0.02), illiteracy (=0.04), household density per residential unit (=1.29), distance between the center of the county and the provincial capital (=0.03), and urbanization (=0.81). The following other risk factors for TB mortality were identified: diabetes (=0.02), human immunodeficiency virus infection (=0.04), infection with TB in the most recent 2 years (=0.07), injection drug use (=0.07), long-term corticosteroid use (=0.09), malignant diseases (=0.09), chronic kidney disease (=0.32), gastrectomy (=0.50), chronic malnutrition (=0.38), and a body mass index more than 10% under the ideal weight (=0.01). However, silicosis had no effect.CONCLUSIONSThe results of this study provide useful information on risk factors for mortality from TB.
Highlights
Tuberculosis (TB) is a global public health problem that causes morbidity and mortality in millions of people each year [1]
This cross-sectional study was conducted in Iran from March 2017 to March 2018 based on data from the National Tuberculosis and Leprosy Registration Center of Iran’s Ministry of Health and Medical Education (MOHME)
Information about possible TB risk factors was gathered, including a history of HIV infection, whether the TB infection occurred in the most recent 2 years, a history of injection drug use (IDU), diabetes, silicosis, long treatment with corticosteroids, malignant disease, chronic kidney failure, gastrectomy and intestinal bypass, chronic malabsorption syndrome, and the patient’s underweight status
Summary
Tuberculosis (TB) is a global public health problem that causes morbidity and mortality in millions of people each year [1]. In 2017, 10 million people contracted TB, and 1.6 million died from the disease (including 0.3 million people with human immunodeficiency virus [HIV]) [2]. This infectious disease typically involves the lungs (pulmonary TB), but can involve other sites of the body (extrapulmonary TB). One of the most important risk factors for TB is poverty. In this context, it has been shown that in households who were poor rel- Several studies have reported that the risk of TB mortality was closely related to the presence of diseases such as HIV, silicosis, and diabetes, as well as individual and social characteristics [15,16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
