Abstract
BackgroundAlthough it is well-known that early detection of colorectal cancer (CRC) is important for optimal patient survival, the relationship of patient and health system factors with delayed diagnosis are unclear. The purpose of this study was to identify the demographic, clinical and healthcare factors related to mode of CRC detection and length of the diagnostic interval.MethodsAll residents of Alberta, Canada diagnosed with first-ever incident CRC in years 2004–2010 were identified from the Alberta Cancer Registry. Population-based administrative health datasets, including hospital discharge abstract, ambulatory care classification system and physician billing data, were used to identify healthcare services related to CRC diagnosis. The time to diagnosis was defined as the time from the first CRC-related healthcare visit to the date of CRC diagnosis. Mode of CRC detection was classified into three groups: urgent, screen-detected and symptomatic. Quantile regression was performed to assess factors associated with time to diagnosis.Results9626 patients were included in the study; 25% of patients presented as urgent, 32% were screen-detected and 43% were symptomatic. The median time to diagnosis for urgent, screen-detected and symptomatic patients were 6 days (interquartile range (IQR) 2–14 days), 74 days (IQR 36–183 days), 84 days (IQR 39–223 days), respectively. Time to diagnosis was greater than 6 months for 27% of non-urgent patients. Healthcare factors had the largest impact on time to diagnosis: 3 or more visits to a GP increased the median by 140 days whereas 2 or more visits to a GI-specialist increased it by 108 days compared to 0–1 visits to a GP or GI-specialist, respectively.ConclusionA large proportion of CRC patients required urgent work-up or had to wait more than 6 months for diagnosis. Actions are needed to reduce the frequency of urgent presentation as well as improve the timeliness of diagnosis. Findings suggest a need to improve coordination of care across multiple providers.
Highlights
It is well-known that early detection of colorectal cancer (CRC) is important for optimal patient survival, the relationship of patient and health system factors with delayed diagnosis are unclear
The purpose of the present study was to: 1) estimate the proportion of CRC patients that are detected via an opportunistic screening visit, urgent and non-urgent symptom visits; 2) identify patient demographic, clinical and healthcare utilization factors related to mode of CRC detection; and 3) identify patient demographic, clinical and healthcare utilization factors related to time to diagnosis for non-urgent cases
A total of 11,241 patients were diagnosed in Alberta with colorectal cancer from 2004 to 2010
Summary
It is well-known that early detection of colorectal cancer (CRC) is important for optimal patient survival, the relationship of patient and health system factors with delayed diagnosis are unclear. The purpose of this study was to identify the demographic, clinical and healthcare factors related to mode of CRC detection and length of the diagnostic interval. Colorectal cancer (CRC) is the second most common cancer in men and the third most common cancer in women in Canada. Every year almost 24,000 Canadians are diagnosed with and 9,200 die from CRC [1]. The diagnosis of CRC is often not straightforward. Symptoms are often non-specific and commonly occur in benign conditions [2]. Presentation and diagnosis are often delayed until the cancer is advanced [3].
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