Abstract
ABSTRACT 709 clinical mastitis cases were analyzed and treated with antimicrobial combination cephalexin-neomycin and the anti-inflammatory prednisolone. A sample of milk was collected to perform a microbiological culture before starting the treatment and 14 days later. Somatic cell count (SCC) was obtained from samples collected on the day of the clinical case (D0), 14 days after (D14) and 28 days after (D28). Of the total, 435 (61.4%) at the D0 exhibited growth of microorganisms. Of the isolated agents, 365 (84%) were Gram-positive, and 66 (16%) were Gram-negative. A clinical cure was achieved in 63% of cases. Bacteriological cure occurred in 75% of cases. Only at D28 after the clinical case a significant SCC reduction was verified. The logistic regression for clinical cure showed significant effects for days in milk and parity (P< 0.05). For bacteriological cure, there were significant effects of Log (SCC) D0; clinical cure and quarter affected (P< 0.05). In the principal component analysis, the Temperature-Humidity Index was associated with reduced clinical cure of clinical mastitis cases.
Highlights
Given the complexity of factors related to the occurrence of mastitis in dairy cows and the damages caused by it, the use of antimicrobial therapy is still the main strategy for the treatment of intramammary infections (Roberson, 2012)
In order to evaluate the efficacy of intramammary therapy in clinical mastitis cases, the following parameters may be used: clinical cure (CC), somatic cell count (SCC) and bacteriological cure (BC), which the last one is the best criteria for evaluation antimicrobial treatment efficacy (Bradley and Green, 2009)
In this line of reasoning, the lack of pathogen recovery in the microbiological analysis of milk samples can be due to the low number of shedding bacteria from clinical mastitis cases associated with the effective control of infection by the cow’s immune response (Pinzón-Sánchez and Ruegg, 2011) suggesting spontaneous cure of IMI
Summary
Given the complexity of factors related to the occurrence of mastitis in dairy cows and the damages caused by it, the use of antimicrobial therapy is still the main strategy for the treatment of intramammary infections (Roberson, 2012). The limitations to identify the causative agent at the onset of clinical symptoms is one of the reasons for the development of intramammary drugs in combination to cover a wide range of microorganisms, and several therapeutic protocols are frequently performed. The factors related to the cow include, for example, SCC, age, stage of lactation, quarter location, parity and effectiveness of the cow’s immune response (Bradley and Green, 2009; Pinzón-Sánchez and Ruegg, 2011)
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