Abstract
Both the management and caregiving intervention of people living with HIV (PLWH), especially during acute HIV-1 infection, represent a public health issue and a form of social support. This current study analyzed the demographic and clinical factors associated with antiretroviral therapy (ART) adherence of PLWH from positive HIV diagnosis to ART initiation in a tertiary Chinese hospital in Beijing. A total of 200 participants diagnosed with acute HIV-1 infection were enrolled in this study. We collected demographic and clinical data by the use of a self-reported questionnaire. Bivariate and multivariate logistic regressions were used to determine associations between potential variables and outcomes. We found that medication adherence was impacted by years of ART and number of reminders (all P < 0.05). In addition, medication adherence was associated with viral load at 48 weeks (P = 0.035). Future studies are needed to investigate effective interventions that could facilitate ART adherence.
Highlights
The total number of people living with HIV (PLWH) and acquired immunodeficiency syndrome (AIDS) was 831 225 by the end of July 2018 in China [1]
In China, rapid upward trends occurred in the proportion of HIV-1-infected men who have sex with men (MSM), the percentages of which increased by 7.3%, 12.2%, 29.4%, and 25.8% in 2005, 2007, 2011, and 2014, respectively, suggesting that the MSM constitute the population in which HIV1 transmission is rapidly increasing [4, 6,7,8,9]
People living with acute HIV were identified and treated under early antiretroviral therapy (ART) with tenofovir disoproxil fumarate (TDF), lamivudine (3TC), and efavirenz (EFV), all of which are recommended as a first-line regimen in China
Summary
The total number of people living with HIV (PLWH) and acquired immunodeficiency syndrome (AIDS) was 831 225 by the end of July 2018 in China [1]. Acute and early HIV-1 infection is a major contributor to the epidemic spread of HIV and limiting this spread through “test and treat” strategies may require treatment of persons during the acute phase of infection [11, 16, 17]. Intervention during this stage of infection can dramatically reduce HIV transmission [12, 18,19,20]. It is very important to understand the demographic and clinical factors affecting the increased HIV epidemic of MSM in Beijing and to promote HIV testing, prevention counseling, and other health care and social services that could reduce HIV and STI transmission
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